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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Fig. 4

FNDC5 deficiency enhanced palmitate-induced inflammation and NOX4 expression in primary cardiomyocytes (CMs). a Effects of palmitate (PA, 400 μM) treatment on Tnf-α, Il1b and Il6 mRNA levels in CMs of WT and FNDC5−/− mice. b Effects of PA treatment on NOX2 and NOX4 protein level in CMs of WT and FNDC5−/− mice. The measurement was 24 h after PA treatment for measuring the mRNA levels or protein levels. PA: Palmitate; Veh: Vehicle; F−/−: FNDC5−/−. Values are mean ± SEM. *P < 0.05 vs. Veh. P < 0.05 vs. CMs-WT. n = 3

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