Renal function | CKD (3 to 5 stages) | CKD (4 and 5 stages) | CKD (3 stage) | ||||||
---|---|---|---|---|---|---|---|---|---|
No-KA (n = 175) | KA (n = 148) | p value* | No-KA (n = 52) | KA (n = 70) | p value* | No-KA (n = 123) | KA (n = 78) | p value* | |
eGFR (mL/min/1.73 m2) | |||||||||
Baseline | 38.7 ± 14.1 | 30.7 ± 13.1 | 0.000 | 20.7 ± 6.2 | 19.1 ± 6.8 | 0.187 | 46.4 ± 8.4 | 41.1 ± 7.4 | 0.000 |
End-point | 43.3 ± 20.7 | 31.4 ± 17.5 | 0.000 | 21.8 ± 11.5 | 19.4 ± 13.0 | 0.295 | 52.4 ± 16.5 | 42.1 ± 13.5 | 0.000 |
Scr (μmol/L) | |||||||||
Baseline | 187.0 ± 98.1 | 226.4 ± 107.7 | 0.001 | 296.7 ± 116.2 | 305.5 ± 108.4 | 0.669 | 140.6 ± 28.2 | 155.3 ± 28.4 | 0.000 |
End-point | 186.3 ± 116.2 | 246.1 ± 136.8 | 0.000 | 298.1 ± 130.2 | 337.6 ± 140.2 | 0.115 | 139.0 ± 67.8 | 163.9 ± 60.1 | 0.009 |
BUN (mmol/L) | |||||||||
Baseline | 10.2 ± 5.2 | 11.9 ± 5.6 | 0.008 | 15.4 ± 6.2 | 15.6 ± 5.6 | 0.854 | 8.0 ± 2.5 | 8.5 ± 2.7 | 0.233 |
End-point | 10.1 ± 5.4 | 13.8 ± 8.0 | 0.000 | 14.7 ± 5.8 | 19.0 ± 8.3 | 0.002 | 8.1 ± 3.7 | 9.2 ± 3.9 | 0.053 |
UA (μmol/L) | |||||||||
Baseline | 412.7 ± 113.4 | 425.3 ± 100.1 | 0.293 | 437.6 ± 114.9 | 422.2 ± 112.6 | 0.462 | 402.1 ± 111.5 | 428.1 ± 88.0 | 0.068 |
End-point | 383.8 ± 89.1 | 373.8 ± 83.8 | 0.307 | 399.8 ± 105.0 | 357.3 ± 94.2 | 0.023 | 377.0 ± 81.0 | 388.9 ± 70.3 | 0.289 |
\( HCO_{3}^{ - } \) (mmol/L) | |||||||||
Baseline | 22.5 ± 3.3 | 22.3 ± 3.1 | 0.546 | 20.7 ± 3.0 | 21.0 ± 2.9 | 0.493 | 23.2 ± 3.1 | 23.4 ± 2.8 | 0.762 |
End-point | 24.1 ± 2.7 | 22.9 ± 2.7 | 0.000 | 22.8 ± 2.5 | 21.8 ± 2.2 | 0.018 | 24.6 ± 2.6 | 23.9 ± 2.6 | 0.054 |