TY - JOUR AU - Wang, Meng AU - Xu, Huzi AU - Chong Lee Shin, Octavia Li-Sien AU - Li, Li AU - Gao, Hui AU - Zhao, Zhi AU - Zhu, Fan AU - Zhu, Han AU - Liang, Wangqun AU - Qian, Kun AU - Zhang, Chunxiu AU - Zeng, Rui AU - Zhou, Hanjing AU - Yao, Ying PY - 2019 DA - 2019/04/11 TI - Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways JO - Journal of Translational Medicine SP - 122 VL - 17 IS - 1 AB - Keto-analogues administration plays an important role in clinical chronic kidney disease (CKD) adjunctive therapy, however previous studies on their reno-protective effect mainly focused on kidney pathological changes induced by nephrectomy. This study was designed to explore the currently understudied alternative mechanisms by which compound α-ketoacid tablets (KA) influenced ischemia–reperfusion (IR) induced murine renal injury, and to probe the current status of KA administration on staving CKD progression in Chinese CKD patients at different stages. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-1856-9 DO - 10.1186/s12967-019-1856-9 ID - Wang2019 ER -