Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Table 7 Comparison of selected elements of porcine models of NAFLD/NASH and human NAFLD/NASH

Characteristics	Humans adult type [28]	Humans pediatric type [40]	Göttingen Minipigs (present study)	Ossabaw miniature swine [12]	Ossabaw miniature swine [10]	Bama minipigs [13]	Microminipigs [11]
Steatosis, macro	Yes	Yes	Minimal	3 out of 7	No	No	–
Steatosis, micro	No	No	No	Yes	–	Yes^a	Yes
Fibrosis, perisinusoidal	Yes/No	No	Yes	Yes	Yes	–	No
Fibrosis, portal	No	Yes	Yes	Yes	Yes	Yes	No
Inflammation, lobular	Yes	No	Yes	4 out of 7	No	Yes	Yes
Inflammation, portal	No	Yes	Yes	No	–	Yes	–
Hepatocellular ballooning	Yes	No	No	Yes^b	Yes^b	No	Yes^b
↑ triglycerides liver content	–	–	No	Yes	No	–	Yes
↑ cholesterol liver content	–	–	Yes	–	Yes	–	Yes^c
↑ ALT	Yes/No	Yes/No	No	No	No	Yes	No
↑ AST	–	Yes/No	No	Yes	Yes	Yes	Yes
Hypercholesterolemia	–	–	Yes	Yes	Yes	Yes	Yes
Hypertriglyceridemia	Yes	Yes	Yes	Yes	Yes¹	Yes	No

Selected histopathological elements, biochemical analyses of liver tissue content of lipids and circulating biomarkers from human and different pig studies. The study of Li et al. [43] is not included as relevant information for comparison is missing
ALT Alanine transaminase, AST Aspartate transaminase, – Not mentioned
^aOnly present in Sudan III staining
^bNot typical human-like hydropic degeneration (ballooning)
^cGiven as cholesterol esters
¹Not significantly different from control group

ISSN: 1479-5876