Fig. 7
From: Crosstalk between tumor cells and lymphocytes modulates heparanase expression
Induction of heparanase (HPSE) and heparanase-2 (HPSE2) expression in circulating lymphocytes by tumor cells. a circulating lymphocytes present low expression of HPSE and HPSE2 and secrete low number of exosomes with a low content of heparan sulfate (HS); b tumor cells secrete a larger number of exosomes which have higher content of HS, as well as higher number of HS free chains; c lymphocytes in the presence of tumor cells (co-culture) express higher level of HPSE and HPSE2 and also secrete an increased number of exosomes and free heparan sulfate chains compared to lymphocytes that do not contact tumor cells; d lymphocytes incubated with co-culture conditioned medium in the presence of anti-heparan sulfate proteoglycan, syndecan-1 (anti-syn1), as well as in the presence of the enzyme heparitinase II express exosomes with low level of HPSE and HPSE2 and less amount of HS