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Table 2 Multivariate analysis of PCDH17 expression for overall survival and disease-free survival in the TCGA cohort

From: Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia

Variables

Overall survival

Disease-free survival

Hazard ratio (95% CI)

P

Hazard ratio (95% CI)

P

Full cohort

(n = 173)

(n = 171)

PCDH17 a

2.04 (1.37–3.04)

< 0.001

1.89 (1.19–2.98)

0.007

Ageb

2.90 (1.94–4.34)

< 0.0001

1.52 (0.96–2.43)

0.08

WBC countc

–

–

2.14 (1.36–3.39)

0.001

Cytogenetic riskd

1.84 (1.28–2.65)

0.001

1.39 (0.95–2.04)

0.09

TP53 e

2.76 (1.37–5.55)

0.004

2.64 (0.93–7.47)

0.07

DNMT3A e

1.61 (1.05–2.48)

0.03

1.41 (0.85–2.33)

0.18

RUNX1 e

1.75 (0.94–3.26)

0.08

–

–

CN-AML

(n = 80)

(n = 80)

PCDH17 a

2.02 (1.13–3.62)

0.02

1.79 (0.93–3.44)

0.08

Ageb

2.38 (1.35–4.19)

0.003

2.19 (1.10–4.36)

0.03

WBC countc

1.42 (0.81–2.48)

0.22

1.65 (0.89–3.04)

0.11

FLT3-ITDf

–

–

1.34 (0.60–2.99)

0.47

TP53 e

–

–

4.09 (0.46–36.02)

0.20

DNMT3A e

1.99 (1.13–3.52)

0.02

2.15 (1.15–4.03)

0.02

IDH1 e

0.61 (0.21–1.78)

0.36

0.68 (0.22–2.08)

0.49

  1. Hazard Ratio > 1 or Hazard Ratio < 1 indicate a higher or lower risk. Only variables with a univariable P ≤ 0.20 were included in the multivariable models. See Additional file 1: Table S3 for a full list of variables evaluated in univariable analysis
  2. TCGA The Cancer Genome Atlas, CI confidence interval, WBC white blood cells, CN-AML cytogenetically normal AML, ITD internal tandem duplication
  3. aLow vs high expression
  4. b > 60 vs ≤ 60 years
  5. c ≥ 30 vs < 30 × 109/L
  6. dAdverse vs intermediate vs favorable
  7. eMutated vs wild type
  8. fPresent vs absent