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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

Fig. 3

Flow diagram showing steps taken during OZ439 in vitro solubilization tests. Following intestinal fluid addition in step 3, the maximum theoretical concentration of OZ439 was approximately 0.535 mg/mL. Pelleted NPs (after step 5) or bile salts (after step 7) are denoted by white ovals. As dissolution matching 100% of theoretical dissolution was achieved via this protocol, we found that the method results in negligible OZ439 losses despite its several steps

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