Fig. 3
From: Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy
Flow diagram showing steps taken during OZ439 in vitro solubilization tests. Following intestinal fluid addition in step 3, the maximum theoretical concentration of OZ439 was approximately 0.535 mg/mL. Pelleted NPs (after step 5) or bile salts (after step 7) are denoted by white ovals. As dissolution matching 100% of theoretical dissolution was achieved via this protocol, we found that the method results in negligible OZ439 losses despite its several steps