TY - JOUR AU - Ristroph, Kurt D. AU - Feng, Jie AU - McManus, Simon A. AU - Zhang, Yingyue AU - Gong, Kai AU - Ramachandruni, Hanu AU - White, Claire E. AU - Prud’homme, Robert K. PY - 2019 DA - 2019/03/22 TI - Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy JO - Journal of Translational Medicine SP - 97 VL - 17 IS - 1 AB - OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for low and middle income countries (LMICs), any process to create or formulate such a therapeutic must be inexpensive at scale, and the resulting formulation must survive without refrigeration even in hot, humid climates. We here demonstrate the scalability and stability of a nanoparticle (NP) formulation of OZ439. Previously, we applied a combination of hydrophobic ion pairing and Flash NanoPrecipitation (FNP) to formulate OZ439 NPs 150 nm in diameter using the inexpensive stabilizer hydroxypropyl methylcellulose acetate succinate (HPMCAS). Lyophilization was used to process the NPs into a dry form, and the powder’s in vitro solubilization was over tenfold higher than unprocessed OZ439. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-1849-8 DO - 10.1186/s12967-019-1849-8 ID - Ristroph2019 ER -