Fig. 2

Effect of TSP4-BMSCs on HUVEC angiogenesis. a–c VEGF, TGFβ and TSP4 level in the supernatant of HUVECs incubated with BMSCs was detected by ELISA. Data are expressed as the mean ± SD. **p < 0.01. d, e Effect of TSP4-BMSCs on the proliferation and migration of HUVECs at 24 h and 48 h by wound healing test. Data are expressed as the mean ± SD. **p < 0.01, *p < 0.05. f, g Effect of TSP4-BMSCs on HUVEC tube formation at 48 h. Data are expressed as the mean ± SD. **p < 0.01. h, i The effect of TSP4-BMSCs on angiogenesis was examined by arterial ring experiment. Data are expressed as the mean ± SD. **p < 0.01