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Table 1 Clinical and biochemical characteristics of patients with ischemic heart disease according to the presence of type-2 diabetes mellitus and control group

From: Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes

Variables IHD-T2DM (n = 23) IHD-NoT2DM (n = 22) Control (n = 23) P value* P value** P value*** P value
Age (years) 64.2 ± 10.1 65 ± 10.8 62 ± 10 0.451 0.302 0.196 0.298
Male gender 18 (78.3%) 18 (81.8%) 15 (65.2%) 0.530 0.257 0.257 0.467
BMI (kg/m2) 28.6 ± 4.6 28.5 ± 4.5 27.8 ± 4.1 0.734 0.675 0.410 0.689
Smoking 17 (73.9%) 16 (72.7%) 12 (52.2%) 0.545 0.352 0.373 0.498
Obesity 13 (56.5%) 11 (50%) 10 (43.4%) 0.362 0.197 0.456 0.241
Hypertension 20 (86.9%) 18 (81.8%) 17 (74%) 0.314 0.176 0.422 0.217
Dyslipidemia 19 (82.6%) 18 (81.8%) 16 (69.6%) 0.574 0.117 0.176 0.196
Cerebrovascular disease 2 (8.7%) 1 (4.5%) 2 (8.7%) 0.500 0.744 0.482 0.485
Cardiovascular disease history 23 (100%) 22(100%) 2 (8.7%) 0.687 0.035 0.040 0.048
Cardiovascular disease family history 6 (26.1%) 3 (13.6%) 1 (4.3%) 0.146 0.078 0.357 0.176
Left ventricular ejection fraction (%) 55 ± 6 53 ± 6 52 ± 6 0.352 0.146 0.397 0.284
Left ventricular ejection fraction ≤ 40% 5 (21.7%) 4 (18.2%) 4 (17.4%) 0.112 0.115 0.651 0.209
Framinghan score 14.4 ± 8.1 16.8 ± 9.5 9.6 ± 5.8 0.546 0.112 0.048 0.093
Medications, n (%)
 Statin 12 (52.2) 8 (36.4) 9 (39.1) 0.354 0.346 0.850 0.423
 ACEI/ARB 10 (43.4) 5 (22.7) 6 (26.1) 0.231 0.205 0.796 0.215
 Beta-blocker 14 (60.9) 8 (36.4) 15 (65.2) 0.129 0.922 0.076 0.095
Biochemical data
 Glucose (mg/dL) 167 ± 31 100 ± 29 100 ± 29 < 0.001 < 0.001 0.919 < 0.001
 HbA1c (%) 7.9 ± 1 5.7 ± 0.5 5.5 ± 0.5 < 0.001 < 0.001 0.186 < 0.001
 Insulin (μIU/mL) 19.6 ± 15 7 ± 4.4 9.4 ± 5 0.133 0.215 0.500 0.187
 HOMA-IR 10.3 ± 8.3 1.7 ± 1 2.5 ± 1.6 0.133 0.111 0.527 0.111
 Cholesterol (mg/dL) 163 ± 31 157 ± 28 150 ± 29 0.641 0.108 0.158 0.199
 LDL cholesterol (mg/dL) 101 ± 21 99 ± 19 103 ± 21 0.910 0.925 0.970 0.899
 HDL cholesterol (mg/dL) 34 ± 6 41 ± 9 44 ± 9 0.033 0.001 0.427 0.004
 Triglycerides (mg/dL) 189 ± 59 169 ± 41 148 ± 40 0.202 0.004 0.133 0.014
 ApoB-100/ApoA-1 0.523 ± 0.101 0.743 ± 0.230 0.757 ± 0.240 0.267 0.222 0.998 0.287
 OxLDL (units/L) 63.4 ± 10 54.4 ± 5.3 51.0 ± 8.6 0.118 0.033 0.472 0.081
 LRP1 (ng/mL) 0.925 ± 0.438 0.677 ± 0.493 0.789 ± 0.267 0.093 0.036 0.257 0.067
 CRP (mg/dL) 71.6 ± 42 27.3 ± 19 19.2 ± 22 0.138 0.056 0.354 0.104
Characteristics of coronary disease
 Multivessel coronary disease 19 (82.6%) 13 (59.1%)   0.01    
 > 50% stenosis LMA 16 (69.6%) 10 (45.5%)   0.01    
 > 50% stenosis ADA 22 (95.7%) 16 (72.7%)   0.01    
 > 50% stenosis CA 18 (78.3%) 13 (59.1%)   0.01    
 > 50% stenosis RCA 19 (85.6%) 14 (63.6%)   0.01    
 Gensini score 45 ± 14 34 ± 12   < 0.001    
  1. Values are shown as mean ± SD and frequencies (percentages)
  2. ADA, anterior descending artery; CA, circumflex artery; IHD-DM, ischemic heart disease-diabetes mellitus; IHD-NDM, ischemic heart disease-non diabetes mellitus; CRP, C-reactive protein; BMI, body mass index; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment for insulin resistance IU/L, international units/liter; kg/m2, kilogram/square metre; LDL, low-density lipoprotein; LMA, left main artery; mg/dL, milligram/deciliter; mmol/L, milimol/liter; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker; OxLDL, oxidized low-density lipoprotein; LRP1, low density lipoprotein receptor-related protein 1; RCA, right coronary artery
  3. P value: overall comparison for all groups. * P value: IHD-T2DM vs. IHD-NoDM; ** P value: IHD-T2DM vs. control group; *** P value: IHD-NoDM vs. control group