Nuclear shape, architecture and orientation features from H&E images are able to predict recurrence in node-negative gastric adenocarcinoma

Table 5 Multivariate survival analysis conducted on D2

Variable	P value	HR (95% CI)
T-stage (T1/T2 vs. T3/T4)	0.34	1.42 (0.69–2.42)
Histology stage (W/M vs. poorly)	0.16	3.61 (0.60–21.64)
Manual nuclear atypia grading (low vs. high)	0.23	2.55 (0.55–11.75)
Invasion depth (out vs. in)	0.51	0.56 (0.09–3.14)
Tumor diameter (< 5 cm vs. ≥ 5 cm)	0.62	0.37 (0.09–18.83)
NGAHIC (positive vs. negative)	1.6 × 10 ⁻⁴	17.24 (3.93–75.60)

CI confidence interval, HR hazard ratio, NGAHIC image classifier, out out of serosa, in invasion of serosa, W/M well and moderate-differentiate
P value in italic is statistically significant, P < 0.05

ISSN: 1479-5876