Table 1 177 of the potential targets with docking score > 6.0
From: Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis
Protein name | PDB ID | Docking scores (pKd/pKi) | Protein name | PDB ID | Docking scores (pKd/pKi) | Protein name | PDB ID | Docking scores (pKd/pKi) |
|---|---|---|---|---|---|---|---|---|
Up-regulated genes | ||||||||
 CCL3 | 3FPU | 7.775 | IL23A | 3D85 | 6.835 | MMP3 | 1HY7 | 6.668 |
 IL10 | 2ILK | 7.354 | NT5C | 2I7D | 6.826 | ISG15 | 1Z2M | 6.664 |
 BDH2 | 2AG5 | 7.183 | CCL8 | 1ESR | 6.824 | TPRKB | 3ENP | 6.659 |
 GGCT | 3CRY | 7.093 | EFNA5 | 1SHX | 6.824 | MMP12 | 1Y93 | 6.512 |
 GSTM2 | 2C4J | 7.062 | PRPS1 | 2H06 | 6.824 | PAOX | 1W6G | 6.509 |
 DCXR | 3D3W | 6.981 | MTSS1 | 2D1L | 6.822 | ACY1 | 1Q7L | 6.431 |
 CBR2 | 1CYD | 6.941 | GAS6 | 1H30 | 6.81 | JAK3 | 3LXL | 6.417 |
 ICAM1 | 1IAM | 6.941 | CCL2 | 1DOK | 6.8 | JMJD6 | 3K2O | 6.414 |
 AMBP | 1BIK | 6.929 | PRDX1 | 3HY2 | 6.799 | LY86 | 3M7O | 6.389 |
 SDC4 | 1OBY | 6.929 | DDIT4 | 3LQ9 | 6.79 | TLR1 | 2Z7X | 6.375 |
 C1QB | 2WNV | 6.922 | LMNA | 1IFR | 6.775 | CUTA | 1KR4 | 6.354 |
 CD69 | 3HUP | 6.92 | RRAS | 2FN4 | 6.775 | PIM1 | 1XWS | 6.342 |
 TRPV2 | 2ETB | 6.915 | BST2 | 3NWH | 6.761 | EVL | 1QC6 | 6.34 |
 NPC2 | 1NEP | 6.907 | CD14 | 1WWL | 6.751 | TLR6 | 3A79 | 6.31 |
 UCK2 | 1UJ2 | 6.903 | DAPP1 | 1FAO | 6.747 | GATM | 1JDW | 6.302 |
 GSTA2 | 1ML6 | 6.9 | IL12A | 1F45 | 6.746 | PCSK9 | 2QTW | 6.219 |
 LAG3 | 2FO1 | 6.89 | SOCS3 | 2HMH | 6.742 | APOM | 2WEW | 6.213 |
 BAX | 2G5B | 6.888 | TREX1 | 2IOC | 6.731 | GLB1 | 3G46 | 6.207 |
 GSTA1 | 1K3Y | 6.881 | ARF2 | 1J2 J | 6.73 | ISG20 | 1WLJ | 6.203 |
 TLR4 | 2Z62 | 6.871 | MEFV | 2WL1 | 6.709 | RGS10 | 2IHB | 6.192 |
 NR1D1 | 1A6Y | 6.87 | THYN1 | 3EOP | 6.685 | VDR | 1IE9 | 6.159 |
 CBR3 | 2HRB | 6.869 | LTC4S | 2UUI | 6.681 | CCND1 | 2W96 | 6.144 |
 APBB3 | 2DYQ | 6.864 | CASP8 | 1QTN | 6.678 | MMP14 | 3C7X | 6.135 |
 LXN | 2BO9 | 6.855 | MMP13 | 830C | 6.677 | TNNI2 | 1A2X | 6.118 |
 PRL | 3D48 | 6.855 | IL2RG | 2B5I | 6.676 |  |  |  |
 GRHPR | 2GCG | 6.841 | MIF | 3DJH | 6.673 |  |  |  |
Down-regulated genes | ||||||||
 STAT3 | 1BG1 | 7.945 | RNF4 | 2XEU | 6.841 | KIF11 | 1X88 | 6.645 |
 NCOR1 | 3KMZ | 7.085 | AGFG1 | 2OLM | 6.837 | DCK | 1P5Z | 6.641 |
 NCOA4 | 1T5Z | 7.084 | FUS | 1SVF | 6.837 | AHSP | 1Z8U | 6.629 |
 ACADM | 1EGD | 7.073 | ANXA3 | 1AXN | 6.836 | NR1H2 | 1PQ9 | 6.624 |
 KAT5 | 2OU2 | 7.065 | RBM12 | 2EK1 | 6.834 | FCHO2 | 2V0O | 6.593 |
 SDF2 | 3MAL | 7.065 | IPMK | 2IEW | 6.832 | NQO2 | 2QWX | 6.592 |
 TDG | 1WYW | 7.021 | SCP2 | 2SAS | 6.824 | RGS3 | 3FBK | 6.584 |
 MYLK | 2O5G | 7.005 | OGT | 1MGT | 6.82 | AQP1 | 1J4N | 6.582 |
 TOP2A | 1ZXM | 7.002 | HVCN1 | 3A2A | 6.816 | MMP8 | 1I76 | 6.484 |
 ITK | 3MIY | 6.98 | PDE6D | 1KSH | 6.81 | MKL1 | 2V52 | 6.459 |
 UBA1 | 3CMM | 6.971 | LRRK2 | 2ZEJ | 6.809 | PTPRE | 2JJD | 6.438 |
 DDX58 | 3LRR | 6.966 | CDK9 | 3MI9 | 6.808 | GET4 | 2WPV | 6.414 |
 NCF1 | 1KQ6 | 6.944 | GGA1 | 1J2J | 6.8 | XDH | 3NRZ | 6.407 |
 PYGL | 3DDS | 6.936 | IL6RA | 1N26 | 6.797 | TESC | 1NJK | 6.398 |
 RAP2A | 1KAO | 6.935 | MGST1 | 2H8A | 6.786 | GNA12 | 1ZCA | 6.384 |
 GRK6 | 2ACX | 6.924 | PPOX | 2IVD | 6.784 | YKT6 | 3KYQ | 6.377 |
 CD47 | 2JJS | 6.923 | SRSF1 | 3BEG | 6.773 | ARAF | 8ABP | 6.346 |
 KIF2A | 2GRY | 6.922 | SNX17 | 3LUI | 6.772 | SGOL1 | 3FGA | 6.336 |
 RAB28 | 2HXS | 6.919 | CSF3R | 1CD9 | 6.759 | PPM1A | 1A6Q | 6.331 |
 IRF3 | 3A77 | 6.916 | MAFG | 3A5T | 6.756 | HIP1R | 1R0D | 6.319 |
 SUMO1 | 2UYZ | 6.912 | RALA | 1U8Z | 6.756 | LBP | 2HPS | 6.317 |
 GP1BA | 1P9A | 6.903 | NCK1 | 2CI9 | 6.742 | RXRB | 1H9U | 6.283 |
 PDIA3 | 2H8L | 6.896 | PADI4 | 2DEW | 6.738 | GDI1 | 2BCG | 6.27 |
 VPS54 | 3N1E | 6.887 | STIP1 | 1ELW | 6.738 | PTPRC | 1YGR | 6.268 |
 ATG3 | 2DYT | 6.883 | EXOC2 | 1UAD | 6.719 | ENO1 | 2AL1 | 6.225 |
 NPY | 1R9N | 6.881 | TIMP2 | 2E2D | 6.719 | WNK1 | 3FPQ | 6.169 |
 SPC25 | 2FTX | 6.878 | EP300 | 3BIY | 6.707 | CAT | 1Q23 | 6.105 |
 RAF1 | 1C1Y | 6.87 | PRG2 | 1H8U | 6.701 | PGAM1 | 1YFK | 6.07 |
 AP2S1 | 2VGL | 6.859 | TGM3 | 1VJJ | 6.701 | DDX47 | 3BER | 6.062 |
 FIS1 | 2PQR | 6.855 | ETFA | 1O97 | 6.694 | PSIP1 | 2B4J | 6.019 |
 GPX1 | 2V1M | 6.854 | DOK1 | 2V76 | 6.679 | ANXA1 | 1HM6 | 6.014 |
 DAPK2 | 2A2A | 6.853 | UCHL5 | 3A7S | 6.665 | GSTP1 | 2A2R | 6.007 |
 RHOU | 2Q3H | 6.853 | ALDH2 | 1O04 | 6.655 | RAB1B | 3NKV | 6.007 |