Chronic abdominal vagus stimulation increased brain metabolic connectivity, reduced striatal dopamine transporter and increased mid-brain serotonin transporter in obese miniature pigs

Table 1 Statistical parameter mapping analysis of activation patterns (local maxima) obtained from ¹⁸FDG PET scan in stimulated animals compared to sham

Coordinate of local maximum (x, y, z in mm)	P_corrected (voxel level)	T-value (voxel level)	Tentative anatomic localization
2, − 11, − 8	0.001	7.46	Periaqueducal grey
− 4, − 6, − 6	0.001	6.96	Periaqueducal grey
6, 9, − 2	0.001	6.32	Ventral anterior thalamus R
− 0, 9, − 9	0.003	5.46	Medial hypothalamic area
− 18, 7, − 4	0.002	6.06	Amygdala L
− 10, 28, − 6	0.004	4.88	Insula L

The analysis was performed with the cluster size of 100 voxels. Values of P were presented using FDR correction. Tentative anatomic localization is given based on interpretation of the projection of the activation pattern on the pig brain anatomic atlas published by our group [22]

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