Table 1 Clinicopathological characteristics

Age, median (range, year)

70 (44–85)

Gender

Male

Female

Histology

Adenocarcinoma

Squamous

NOS

Stage

IIIB

IV

ECOG PS

0

1

2

Smoking habits

Never smoker

Former smoker

Smoker

Prior lines of therapy

Median 2 (range 1–6)

1

2

3

≥ 4

CEA (ng/ml) baseline

Median (range)

6.6 (0.80–2615)

Normal (< 5)

Elevated (≥ 5)

CYFRA 21-1 (ng/ml) baseline

Median (range)

5.0 (0.2–126.4)

Normal (< 3.3)

Elevated (≥ 3.3)

NSE (ng/ml) baseline

Median (range)

7.5 (3.1–46.8)

Normal (< 3.3)

Elevated (≥ 3.3)