Production of a cellular product consisting of monocytes stimulated with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for human use

Table 5 Mouse studies for IND application

Dose level	Monocytes total number	Sylatron^® Peginterferon alfa2b	Actimmune^® Interferon gamma-1b
Vehicle	0	0	0
Low dose	7.5 × 10⁴	17 ng	1.7 ng
Mid dose	7.5 × 10⁵	17 ng	1.7 ng
High dose	7.5 × 10⁵	100 ng	16.7 ng
Fivefold max	7.5 × 10⁵	500 ng	85 ng

ISSN: 1479-5876