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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Fig. 2

Analysis of anti-NFATc1 staining: MRONJ (BP) vs. OM vs. ORN vs. control. a Visual field from a MRONJ (BP)-specimen with two giant multinucleated OCs with stained NFATc1+ nuclei (arrowheads). Note that this staining predominantly stains nuclei. b Visual field from a control specimen with an unstained OC (arrowhead). The specimens in a and b underwent anti-NFATc1 staining under the same conditions. c Visualizes the number of NFATc1+ OCs per ROI for each group. d Illustrates the respective labeling indices. *Marks statistical outliers. For detailed data see Table 2. MRONJ (BP) medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy, OC osteoclasts, OM osteomyelitis, ORN osteoradionecrosis, NFATc1 nuclear factor of activated T-cells, cytoplasmic 1; ROI region of interest

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