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Table 2 Basic characteristics of participants in stage-1 study

From: Bioinformatics-based discovery of the urinary BBOX1 mRNA as a potential biomarker of diabetic kidney disease

  HC NA MA OA ESKD UTI BC
Number 14 16 11 12 13 8 8
Age 47.0 ± 8.6 49.9 ± 10.2 64.3 ± 6.7* 60.4 ± 8.9* 64.3 ± 12.2* 49.4 ± 13.3 62.3 ± 10.1*
Gender (male/female) 9/5 7/9 4/7 10/2 11/2 5/3 2/6
eGFR (ml/min/1.73 m2) 101.4 [95.9–110.3] 107.6 [90.6–136.3] 71.1 [40.3–112.1]* 50.5 [30.7–80.7]* 11.9 [8.6–14.7]* 100.4 [84.2–111.9] 113.8 [93.9–140.9]
ACR (mg/g) 5.2 [2.9–8.5] 6.4 [4.8–12.6] 120.6 [85.8–216.6]* 685.9 [414.4–3094.0]* 643.5 [546.3–890.3]* 8.0 [4.4–12.7] 10.7 [7.3–15.0]
Glu (mmol/L) 5.7 [5.2–5.9] 12.0 [8.4–16.8]* 8.9 [6.8–16.4]* 9.6 [6.4–12.8]* 5.7 [4.8–9.2] 5.8 [4.9–6.0] 5.7 [5.5–5.9]
HbA1c (%) 4.9 [4.6–5.3] 10.1 [7.8–10.6]* 8.3 [6.8–11.2]* 8.6 [6.2–9.0]* 6.1 [5.3–8.0] 5.3 [4.9–5.5] 4.9 [4.6–5.5]
SBP (mmHg) 119.2 ± 7.5 126.3 ± 9.5 137.5 ± 13.1* 147.6 ± 21.9* 155.5 ± 24.6* 121.9 ± 11.5 127.1 ± 12.4
DBP (mmHg) 76.4 ± 6.6 79.3 ± 8.2 81.6 ± 9.1 81.7 ± 9.8 78.3 ± 12.6 74.9 ± 5.5 76.4 ± 6.5
Urinary NAG/Cr (U/mol) 0.43 [0.38–0.72] 0.60 [0.44–1.14] 1.30 [0.45–3.70]* 1.90 [0.84–4.81]* 1.71 [1.14–2.60]* 0.51 [0.37–0.74] 1.33 [0.54–2.34]*
  1. Glu, blood glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure
  2. * p < 0.05 compared with HCs