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Table 2 Baseline characteristics between healthy individuals (donors) and kidney transplant recipients

From: Dermal tissue remodeling and non-osmotic sodium storage in kidney patients

Variables

Healthy individuals donors (N = 12)

Renal patients recipients (N = 12)

All

Preemptive

Dialysis

(N = 12)

(N = 7)

(N = 5)

Age (years)

61 [53–67]

52 [43–60]*

51 [48–64]

53 [41–60]

Sex (% male)

33

58

57

60

Length (cm)

166 [161–178]

176 [170–183]

176 [170–182]

175 [168–184]

Weight (kg)

81 [73–91]

77 [70–87]

73 [70–82]

84 [73–94]

BMI (kg/m2)

29 [25–31]

24 [22–28]

24 [22–25]*

26 [23–32]

Blood pressure (mmHg)

 Systolic

138 [129–150]

150 [131–158]

151 [122–165]

149 [136–152]

 Diastolic

80 [72–85]

87 [71–95]

88 [69–98]

86 [63–89]

Time on dialysis, months

–

–

–

13 [8–18]

Dialysis (%)

 Hemodialysis

–

–

–

80

 First peritoneal, switched to hemodialysis

–

–

–

20

Underlying disease (%)

 Healthy donor

100

0

0

0

 IgA Nephropathy

0

17

14

20

 Focal Segmental

0

17

14

20

Glomerulo-sclerosis

 ADPKD

0

33

29

40

 Glomerulonephritis

0

25

29

20

 Other

0

8

14

0

Known comorbidities (%)

 Hypertension

8

67

58

80

 Malignancy

8

8

14

0

 Coronary heart disease

8

17

14

20

 Diabetes mellitus

0

8

0

20

 Other

8

17

14

40

 No relevant comorbidities

67

17

29

0

Drug use (%)

 Anti-hypertensives

42

67

86

40

 Diuretics

0

42*

43*

40*

 Anti-diabetics

0

8

0

20

Dermal sodium content (µmol/mg protein)

0.68 [0.45–0.94] (n = 8)

0.89 [0.59–1.01] (n = 11)

0.98 [0.59–1.12] (n = 7)

0.83 [0.45–0.89] (n = 4)

Laboratory characteristics (day of OR)

 eGFR (mL/min)

91 [81–95]

11 [8–14] ***

11 [10–14]***

8 [6-X]** (n = 3)

 Serum creatinine (umol/L)

68 [63–84]

514 [447–646]***

462 [442–516]***

619 [399–1065]**

 Serum albumin (mmol/L)

44 [43–46]

43 [41–46]

43 [42–50]

42 [40–45]

 Plasma sodium (mmol/L)

141 (140–143]

43 [41–46]

139 [138–142]

137 [137–140]**

 Urine creatinine (mmol/L)

6.5 [4.2–11.9]

6.4 [3.8–8.9]

5.4 [3.2–8.2]

8.6 [6.4–13.1]

 Proteinuria (g/L)

0.04 [0.03–0.06]

1.92 [0.26–2.35]**

0.39 [0.26–6.60]**

2.09 [0.54–2.33]**

 Urine sodium (mmol/L)

85 [60–119]

62 [41–68]*

62 [56–68]

44 [22–77]

 Sodium excretion (mmol/24 h)

128 [20–192]

107 [40–140]

116 [54–166]

107 [17–X] (n = 3)

  1. * Significantly different compared to healthy donors (* p < 0.05, ** p < 0.01, *** p < 0.001)