Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line

Table 3 Distinguishing and validation of 7 PGR co-expressed genes among DEGs

Gene symbol	PGR co-expression (548 EC tissues)		Microarray analysis		GSE17025		Survival curve (542 EC tissues)
	PGR co-expression (548 EC tissues)		Microarray analysis		Pearson score		Survival curve (542 EC tissues)
	Pearson score	Spearman score	LogFC	−Log(p-value)	r	p-value	HR	LogRank p-value
ANO1	0.66	0.72	− 10.78	8.69	0.611	< 0.01	0.38	3.00E−06
CGNL1	0.39	0.45	− 7.19	3.38	0.438	< 0.01	0.48	0.00046
DACH1	0.33	0.39	− 6.67	4.60	0.285	< 0.01	0.79	0.27
SH3YL1	0.58	0.54	− 4.40	6.41	0.416	< 0.01	0.53	0.0027
RUNDC3B	0.43	0.46	− 4.23	4.64	0.235	< 0.1	0.73	0.21
CRISPLD1	0.39	0.39	− 4.09	4.42	0.434	< 0.01	0.64	0.038
SOX17	0.46	0.59	− 4.03	5.83	0.444	< 0.01	0.46	0.00021

PGR co-expression showed correlation analysis among target genes and PGR using Cbioportal website. The third column shows the result of microarray analysis between Ishikawa and IshikawaPR cell. Negative means they were down-regulated in IshikawaPR cell. The fourth column is the PGR correlation analysis of target genes using GSE17025 dataset. Survival curve was performed using Kaplan–Meier plotter. FC, fold change

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