Fig. 7
Protein-protein interaction (PPI) network and identification of MCODEs. a PPI network of 821 DEGs and 8 hub genes. Red represented hub genes (degree ≥ 15 as cut-off criterion). Font size of gene symbol determined by degree of connectivity. The width of the edge was determined by the combined score of the PPI relationship. Hub genes were HSPA1A, EEF1A2, AR, POU5F1, C3, SYK, LPAR1, NMU. b 4 MCODEs identification in the PPI network with MCODE score ≥ 4. The label size was determined according to the degree of connectivity. Yellow represented seed nodes. Red nodes were up-regulated genes and blue nodes were down-regulated genes in IshikawaPR cell