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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line

Fig. 1

Identification of differentially expressed genes (DEGs) in MPA-resistant Ishikawa cell using Morpheus Website. a Overall design of the study. b Volcano plot of the 27831 expressed genes. Red color represented up-regulated genes in IshikawaPR cell than Ishikawa cell and blue color represented down-regulated genes. c Clustering heatmap of the 821 genes exhibiting significantly differential expression, statistically significant DEGs were defined as |Log2Foldchange| > 4 and p-value < 0.05. GO: gene ontology; PPI, protein–protein interaction; TCGA, The Cancer Genome Atlas; PGR, progesterone receptor; RT-PCR, real-time polymerase chain reaction

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