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Table 1 Baseline demographic characteristics of participants of C-STRIDE Study according to NLR

From: Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Variable

Total (n = 938)

NLR ≥ 2.09 (n = 520)

NLR < 2.09 (n = 418)

p value

Age (year)*

52.8 (14.14)

54.0 (14.48)

51.3 (13.58)

0.047**

Sex (men)$

544 (58.00%)

304 (58.46%)

240 (57.42%)

0.747

Ever smoking$

311 (34.2%)

180 (35.7%)

131 (32.3%)

0.276

Drinking ≥ 1 times per day$

189 (21.00%)

101 (20.2%)

88 (22.0%)

0.510

BMI category (kg/m2)#

24.61 (22.04–27.34)

24.61 (22.01–27.42)

24.59 (21.99–27.31)

0.944

HGB (g/L)*

129.2 (22.78)

125.7 (23.00)

133.70 (21.71)

0.183

Systolic blood pressure (mmHg)*

127.51 (16.71)

129.91 (17.88)

124.92 (14.96)

0.537

Diastolic blood pressure (mmHg)*

80.13 (10.48)

81.11 (11.01)

79.08 (9.78)

0.918

Antihypertensive medications token in 2 weeks$

507 (69.5%)

288 (74.0%)

219 (64.4%)

0.005**

Hypertension$

538 (57.4%)

303 (58.3%)

235 (56.2%)

< 0.001**

Uric acid (μmol/L)*

373.59 (132.08)

376.59 (136.42)

369.87 (126.55)

0.208

Serum triglycerides (mmol/L)#

1.66 (1.18–2.39)

1.61 (1.13–2.26)

1.79 (1.21–2.59)

0.021**

Hyperuricemia$

407 (44.3%)

235 (46.2%)

172 (42.0%)

0.201

Total serum cholesterol (mmol/L)#

4.70 (4.01–5.57)

4.59 (3.94–5.39)

4.82 (4.12–5.89)

0.003**

LDL cholesterol (mmol/L)#

2.73 (2.22–3.40)

2.72 (2.20–3.36)

2.74 (2.23–3.48)

0.369

HDL cholesterol (mmol/L)#

1.12 (0.91–1.34)

1.12 (0.93–1.34)

1.12 (0.89–1.34)

0.729

Hyperlipidaemia$

194 (26.6%)

98 (23.7%)

96 (30.5%)

0.039**

Cardiovascular disease$

124 (13.40%)

81 (15.80%)

43 (10.40%)

0.017**

ACR (mg/g creatinine)#

343.05 (75.60–780.51)

420.50 (112.11–312.90)

290.01 (48.20–666.86)

0.000**

ACR group$

814

447

367

0.006**

 1 < 30 mg/g

127 (15.6%)

56 (12.5%)

71 (19.3%)

 

 2 = 30–299 mg/g

248 (30.5%)

130 (29.1%)

118 (32.2%)

 

 3 ≥ 300 mg/g

439 (53.9%)

261 (58.4%)

178 (48.5%)

 

sCa (mmol/L)*

2.22 (0.18)

2.23 (0.18)

2.22 (0.18)

0.735

sP (mmol/L)#

1.17 (1.05–1.31)

1.17 (1.04–1.31)

1.18 (1.05–1.32)

0.925

CKD-MBD$

467 (54.6%)

274 (58.1%)

193 (50.3%)

0.023**

HCO3− (mmol/L)*

25.70 (3.78)

25.54 (3.99)

25.91 (3.49)

0.060

Diabetes$

200 (23.8%)

135 (29.4%)

65 (17.1%)

0.000**

eGFR (mL/min/1.7 m2)*

57.22 (32.67)

48.73 (29.63)

67.78 (33.24)

0.000**

eGFR group$

938

   

 ≥ 60 mL/min/1.73 m2

360 (38.4%)

139 (26.7%)

221 (52.9%)

0.000**

 30–60 mL/min/1.73 m2

345 (36.8%)

212 (40.8%)

133 (31.8%)

 

 15–30 mL/min/1.73 m2

233 (24.8%)

169 (32.5%)

64 (15.3%)

 

High hs-CRP

146 (15.6%)

88 (16.9%)

58 (13.9%)

0.414

  1. The number of missing values for each variable: NLR 0, age 0, eGFR 0, sex 0, education 31, ever smoking 51, drinking ≥ 1 times per day 60, BMI category 211, anemia 0, systolic blood pressure 186, diatolic blood pressure 186, antihypertensive medications token in 2 weeks 334, uric acid 30, total serum cholesterol 338, serum triglycerides 347, LDL cholesterol 428, HDL cholesterol 425, CKD-MBD 0, cardiovascular disease 28, ACR 149, metabolic acidosis 589, pathogenesis chronic 0, high Hs-CRP 668
  2. The denominator of percentage is number of the variable
  3. * The variable is numerical and statistics is mean (standard deviation), p-value calculated based on T test
  4. #The variable is numerical and statistics is Median (Interquartile range), p-value calculated based on Wilcoxon test
  5. $The variable is character and statistics is frequency (percentage), p-value calculated based on Chi-square test
  6. ** Statistically significant at 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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