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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia

Fig. 5

Glycolysis pathway showing how increased PFK-2/FBPase-2 expression and phosphorylation, stimulates glycolysis via increased fructose-2,6-bisphosphate synthesis acting as a powerful allosteric activator of PFK-1. The arrows show how the changes observed in PE are predicted to increase renal glycolysis. PFK-1 phosphofructokinase 1, PFK-2/FBPase-2 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphatase, Fru 2,6-P2 fructose 2,6-bisphosphate, PEP phosphoenolpyruvate, AMPK AMP-activated protein kinase, PKA protein kinase A, PKB protein kinase B

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