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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: How mRNA therapeutics are entering the monoclonal antibody field

Fig. 3

An overview of IVT mRNA based therapeutics. In vitro transcription is performed on a linearized DNA plasmid template containing the coding sequence of interest. Naked mRNA or mRNA complexed in a particle can be delivered systemically or locally. Subsequently, a part of the exogenous naked mRNA or complexed mRNA is taken up by cell-specific mechanisms. Once in the cytoplasm, the IVT mRNA is translated by the protein synthesis machinery of the host cell, after which the protein, depending on its design, can exert its function or be processed as intended

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