Fig. 1
From: How mRNA therapeutics are entering the monoclonal antibody field
Overview of monoclonal antibody variants used in therapy. Next to classical fully murine (left) or human monoclonal antibodies (right), recombinant species are used in therapy (middle). These include chimeric mAbs, composed of human constant regions and murine variable regions, and humanized mAbs, where the hypervariable CDR-domains of the murine antibody are grafted on a human antibody. Clinically applied examples of each are given, including their targets between brackets