TY - JOUR AU - Boström, Azize AU - Scheele, Dirk AU - Stoffel-Wagner, Birgit AU - Hönig, Frigga AU - Chaudhry, Shafqat R. AU - Muhammad, Sajjad AU - Hurlemann, Rene AU - Krauss, Joachim K. AU - Lendvai, Ilana S. AU - Chakravarthy, Krishnan V. AU - Kinfe, Thomas M. PY - 2019 DA - 2019/02/22 TI - Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study JO - Journal of Translational Medicine SP - 53 VL - 17 IS - 1 AB - Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-nociceptive impact of oxytocin has been reported in preclinical and human trials. Cervical non-invasive vagus nerve stimulation (nVNS) emerges as an add-on treatment for the preventive and abortive use in migraine. Less is known about its potential to modulate saliva inflammatory signaling in migraine patients. The rationale was to perform inter-ictal saliva measures of oxytocin and IL-1ß along with headache assessment in migraine patients with 10 weeks adjunctive nVNS compared to healthy controls. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-1801-y DO - 10.1186/s12967-019-1801-y ID - Boström2019 ER -