A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma

Table 1 Association between the plasma circRNA expression levels and clinicopathological characteristics of LUAD patients

Characteristics	n = 153	Hsa_circ_0005962			Hsa_circ_0086414
Characteristics	n = 153	Low (n = 43)	High (n = 110)	P value	Low (n = 117)	High (n = 36)	P value
Age (years)
< 60	74	22	52	0.665	58	16	0.59
≥ 60	79	21	58		59	20
Gender
Female	93	20	73	0.024	66	27	0.046
Male	60	23	37		51	9
Smoking
No	99	23	76	0.097	72	27	0.089
Yes	53	19	34		45	8
Tumor size
≤ 3 cm	99	25	74	0.907	75	24	0.956
> 3 cm	42	11	31		32	10
Lymphatic metastasis
Negative	111	27	84	0.091	87	24	0.366
Positive	42	16	26		30	12
Metastasis
M0	130	33	97	0.075	99	31	0.826
M1	23	10	13		18	5
TNM stage
I	83	20	63	0.282	64	19	0.728
II and III and IV	68	21	47		51	17
CEA
Negative	75	16	59	0.146	56	19	0.337
Positive	45	15	30		37	8
EGFR mutation
Negative	26	10	16	0.287	25	1	0.001
Positive	42	11	31		25	17

ISSN: 1479-5876