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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Fig. 3

Model of the association between bacterial translocation hypothesis and related traits of Crohn’s disease in the pathophysiology of chronic fatigue syndrome. The extent of the intestinal barrier integrity may have a crucial role in the disease development. Peripheral inflammation can evoke central inflammation through the gut-to-brain pathway, causing major CFS signs

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