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Table 2 The Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment among predicted miRNAs and Co-DEGs

From: Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke

Genes Predicted miRNAs Category P value
PDZK1IP1 hsa-miR-1296-5p KEGG pathway Hypertrophic cardiomyopathy (HCM) 0.047
hsa-miR-27a-3p   NF-kappa B signaling pathway 0.022
hsa-miR-27b-3p   Toll-like receptor signaling pathway 0.017
hsa-miR-6895-5p GO terms Negative regulation of energy homeostasis 4E−04
hsa-miR-4725-3p   Calcium ion-dependent exocytosis of neurotransmitter 0.001
   Neurotransmitter receptor activity 0.002
   Regulation of leukocyte migration 0.003
   Smooth muscle hyperplasia 0.011
   Immunoglobulin mediated immune response 0.034
ZNF566 hsa-miR-216b-5p KEGG pathway Valine, leucine and isoleucine biosynthesis 0.320
hsa-miR-1277-5p   Cardiac muscle contraction 0.411
hsa-miR-6783-5p GO terms Regulation of acute inflammatory response 0.007
hsa-miR-369-3p   Commissural neuron differentiation in spinal cord 0.019
hsa-miR-6778-3p   Cardiac vascular smooth muscle cell differentiation 0.020
   MHC protein binding 0.035
   ATP-activated inward rectifier potassium channel activity 0.035
   Mitochondrial translation 0.041
PITX2 hsa-miR-377-3p KEGG pathway TGF-beta signaling pathway 3.00E − 03
hsa-miR-141-3p   Phosphatidylinositol signaling system 0.124
hsa-miR-5692b GO terms Vascular smooth muscle cell differentiation 0.002
hsa-miR-4789-5p   Cell proliferation involved in outflow tract morphogenesis 0.002
hsa-miR-494-3p   Cardiac neural crest cell migration involved in outflow tract morphogenesis 0.002
   Pulmonary myocardium development 0.002
   Atrial cardiac muscle tissue morphogenesis 0.002
   Ventricular cardiac muscle cell development 0.003
   Cardiac muscle cell differentiation 0.006
   Neuron migration 0.014
   Neuron differentiation 0.014
ZFHX3 hsa-miR-494-3p KEGG pathway Regulating pluripotency of stem cells 3E − 07
hsa-miR-758-3p GO terms Positive regulation of myoblast differentiation 0.023
hsa-miR-27a-3p   Negative regulation of myoblast differentiation 0.023
hsa-miR-27b-3p   Regulation of neuron differentiation 0.023
hsa-miR-493-5p   Muscle organ development 0.041