Table 2 The Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment among predicted miRNAs and Co-DEGs

PDZK1IP1

hsa-miR-1296-5p

KEGG pathway

Hypertrophic cardiomyopathy (HCM)

0.047

hsa-miR-27a-3p

NF-kappa B signaling pathway

0.022

hsa-miR-27b-3p

Toll-like receptor signaling pathway

0.017

hsa-miR-6895-5p

GO terms

Negative regulation of energy homeostasis

4E−04

hsa-miR-4725-3p

Calcium ion-dependent exocytosis of neurotransmitter

0.001

Neurotransmitter receptor activity

0.002

Regulation of leukocyte migration

0.003

Smooth muscle hyperplasia

0.011

Immunoglobulin mediated immune response

0.034

ZNF566

hsa-miR-216b-5p

KEGG pathway

Valine, leucine and isoleucine biosynthesis

0.320

hsa-miR-1277-5p

Cardiac muscle contraction

0.411

hsa-miR-6783-5p

GO terms

Regulation of acute inflammatory response

0.007

hsa-miR-369-3p

Commissural neuron differentiation in spinal cord

0.019

hsa-miR-6778-3p

Cardiac vascular smooth muscle cell differentiation

0.020

MHC protein binding

0.035

ATP-activated inward rectifier potassium channel activity

0.035

Mitochondrial translation

0.041

PITX2

hsa-miR-377-3p

KEGG pathway

TGF-beta signaling pathway

3.00E − 03

hsa-miR-141-3p

Phosphatidylinositol signaling system

0.124

hsa-miR-5692b

GO terms

Vascular smooth muscle cell differentiation

0.002

hsa-miR-4789-5p

Cell proliferation involved in outflow tract morphogenesis

0.002

hsa-miR-494-3p

Cardiac neural crest cell migration involved in outflow tract morphogenesis

0.002

Pulmonary myocardium development

0.002

Atrial cardiac muscle tissue morphogenesis

0.002

Ventricular cardiac muscle cell development

0.003

Cardiac muscle cell differentiation

0.006

Neuron migration

0.014

Neuron differentiation

0.014

ZFHX3

hsa-miR-494-3p

KEGG pathway

Regulating pluripotency of stem cells

3E − 07

hsa-miR-758-3p

GO terms

Positive regulation of myoblast differentiation

0.023

hsa-miR-27a-3p

Negative regulation of myoblast differentiation

0.023

hsa-miR-27b-3p

Regulation of neuron differentiation

0.023

hsa-miR-493-5p

Muscle organ development

0.041