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Table 1 The Gene Ontology (GO) terms enrichment for the co-expressed genes of the AF-related stroke

From: Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke

Gene/product GO class (direct) Evidence Evidence with Reference
PDZK1IP1 Integral component of membrane IEA UniProtKB-KW:KW-0812 GO_REF:0000037
Extracellular exosome IDA   PMID:19056867
ZNF566 DNA binding IEA UniProtKB-KW:KW-0238 GO_REF:0000037
Nucleus IEA UniProtKB-SubCell:SL-0191 GO_REF:0000039
Transcription, DNA-templated IEA UniProtKB-KW:KW-0804 GO_REF:0000037
Metal ion binding IEA UniProtKB-KW:KW-0479 GO_REF:0000037
ZFHX3 Negative regulation of transcription from RNA polymerase II promoter IGI UniProtKB:P01104 PMID:10318867
RNA polymerase II proximal promoter sequence-specific DNA binding IDA   PMID:7507206
core promoter sequence-specific DNA binding ISS UniProtKB:Q61329 GO_REF:0000024
Transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC GO:0000122/GO:0000978 GO_REF:0000036
Protein binding IPI UniProtKB:Q13761 PMID:20599712
Nucleus TAS   PMID:1719379
PITX2 Transcription regulatory region sequence-specific DNA binding IDA   PMID:9685346
Transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA UniProtKB:Q9R0W1 GO_REF:0000107
RNA polymerase II transcription coactivator activity IDA   PMID:9685346
Branching involved in blood vessel morphogenesis IEA UniProtKB:P97474 GO_REF:0000107
Vasculogenesis IEA UniProtKB:P97474 GO_REF:0000107
In utero embryonic development IEA UniProtKB:P97474 GO_REF:0000107
Neuron migration IEA UniProtKB:P97474 GO_REF:0000107
Extraocular skeletal muscle development IEA UniProtKB:P97474 GO_REF:0000107
  1. ISS sequence similarity evidence used in manual assertion, IGI genetic interaction evidence used in manual assertion, IDA direct assay evidence used in manual assertion, TAS traceable author statement used in manual assertion, IEA evidence used in automatic assertion, IPI physical interaction evidence used in manual assertion