Fig. 5

Pathological properties in mouse kidneys after pristane treatment. a The kidney pathology was investigated at 9 months post pristane treatment. Glomerular injury with mesangial expansion and lymphocyte infiltration in the kidneys of WT and Lrrk2^−/− mice was determined by H&E staining (400×). b Semiquantitative analysis of glomerulonephritis scores. The scores were obtained based on the number of the glomeruli with endocapillary proliferation, extracapillary proliferation (crescents), the damage grade was evaluated as described in “Methods”. c Representatives of glomerular IgG deposition in the kidneys of WT and Lrrk2^−/− mice (200×). d The mean fluorescence intensity (MFI) of IgG within glomeruli was determined by ImageJ software. Both statistics were based on at least five randomly selected images of each mouse. Each group had at least six mice for pathological analysis. **p < 0.01