Fig. 4

LRRK2 deficiency attenuates pristane-induced antibody production in the mice. a Scheme of experiment design. WT and Lrrk2^−/− mice were intraperitoneally injected with 0.5 mL pristane. Sera were collected monthly for IgG and IgM determination. Mice were sacrificed 9 months later. b Survival rate of WT and Lrrk2^−/− mice after pristane injection. c–f Antibody levels in the sera of WT and Lrrk2^−/− mice were assayed by ELISA at 9 months after pristane injection, including total IgG (c), total IgM (d), anti-SnRNP antibody (e) and anti-dsDNA antibody (f). Each group had at least six mice for antibody analysis. *p < 0.05; ns not significant