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Table 3 Univariate Cox regression analyses of the SII with clinicopathologic characteristics [training cohort (n = 197) and validation cohort (n = 222)]

From: Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer

Variables Training Validation
HR (95% CI) P HR (95% CI) P
Age, years (≤ 60 vs. > 60) 1.238 (0.93–1.64) 0.139 0.907 (0.69–1.19) 0.474
Sex (male vs. female) 1.234 (0.92–1.65) 0.154 1.011 (0.76–1.34) 0.942
Location (head vs. body/tail) 0.845 (0.64–1.12) 0.243 0.933 (0.71–1.23) 0.620
Metastasis (no vs. yes) 1.580 (1.11–2.26) 0.012 1.686 (1.18–2.41) 0.004
CA19-9, U/mL (≤ 37 vs. > 37) 1.580 (1.12–2.23) 0.009 1.191 (0.87–1.64) 0.285
TBIL, μmol/L (≤ 17 vs. > 17) 1.578 (1.09–2.28) 0.015 1.472 (1.03–2.10) 0.033
ALB, g/L (≤ 35 vs. > 35) 0.722 (0.41–1.27) 0.259 0.644 (0.36–1.16) 0.140
ALP, U/L (≤ 125 vs. > 125) 1.101 (0.81–1.50) 0.540 1.272 (0.94–1.72) 0.118
ALT, U/L (≤ 35 vs. > 35) 1.061 (0.77–1.47) 0.719 1.090 (0.79–1.50) 0.598
AST, U/L (≤ 40 vs. > 40) 1.019 (0.70–1.49) 0.922 1.437 (1.00–2.07) 0.052
SII (≤ 440 vs. > 440) 1.549 (1.16–2.06) 0.003 1.458 (1.11–1.92) 0.008
  1. CA carbohydrate antigen, TBIL total bilirubin, ALB albumin, ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, SII systemic immune-inflammation index