Table 3 Univariate Cox regression analyses of the SII with clinicopathologic characteristics [training cohort (n = 197) and validation cohort (n = 222)]
From: Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer
Variables | Training | Validation | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age, years (≤ 60 vs. > 60) | 1.238 (0.93–1.64) | 0.139 | 0.907 (0.69–1.19) | 0.474 |
Sex (male vs. female) | 1.234 (0.92–1.65) | 0.154 | 1.011 (0.76–1.34) | 0.942 |
Location (head vs. body/tail) | 0.845 (0.64–1.12) | 0.243 | 0.933 (0.71–1.23) | 0.620 |
Metastasis (no vs. yes) | 1.580 (1.11–2.26) | 0.012 | 1.686 (1.18–2.41) | 0.004 |
CA19-9, U/mL (≤ 37 vs. > 37) | 1.580 (1.12–2.23) | 0.009 | 1.191 (0.87–1.64) | 0.285 |
TBIL, μmol/L (≤ 17 vs. > 17) | 1.578 (1.09–2.28) | 0.015 | 1.472 (1.03–2.10) | 0.033 |
ALB, g/L (≤ 35 vs. > 35) | 0.722 (0.41–1.27) | 0.259 | 0.644 (0.36–1.16) | 0.140 |
ALP, U/L (≤ 125 vs. > 125) | 1.101 (0.81–1.50) | 0.540 | 1.272 (0.94–1.72) | 0.118 |
ALT, U/L (≤ 35 vs. > 35) | 1.061 (0.77–1.47) | 0.719 | 1.090 (0.79–1.50) | 0.598 |
AST, U/L (≤ 40 vs. > 40) | 1.019 (0.70–1.49) | 0.922 | 1.437 (1.00–2.07) | 0.052 |
SII (≤ 440 vs. > 440) | 1.549 (1.16–2.06) | 0.003 | 1.458 (1.11–1.92) | 0.008 |