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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Macrophages are necessary for skin regeneration during tissue expansion

Fig. 6

A switch from M1- to M2-dominant macrophage response occurs during tissue expansion. a Expanded skin stained for M1 marker iNOS (green) and pan-macrophage marker CD68 (red) at day 7, day 14 and day 35. b M2 marker CD206 (green) and pan-macrophage marker CD68 (red) were stained at day 7, day 14 and day 35. Arrows point to M1 or M2 macrophages. Insets show high-magnification images of the M1 or M2 cells. c The number of iNOS+ CD68+M1 cells and CD206+CD68+ per field in skin ± SD. iNOS, inducible nitric oxide synthase. Five rats sacrificed on day 7, 5 rats sacrificed on day 14 and 6 rats sacrificed on day 35 for statistical analysis. *p ≤ 0.05; **p ≤ 0.01; and ****p ≤ 0.0001

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