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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Macrophages are necessary for skin regeneration during tissue expansion

Fig. 3

Macrophage depletion with clodronate liposomes inhibits skin regeneration during tissue expansion. a Representative expansion area from PBS-lipo (left) and Clo-lipo (right) treated skin followed over time. b Expansion area of the two sides was measured over time. The difference appeared at day 14 (n = 13) and became more evident at day 28 and day 35 (n = 8). c, d H&E staining showed a thicker whole skin thickness in PBS-lipo side than that in Clo-lipo side at days 14 (n = 5, p < 0.01) and day 35 (n = 8, p < 0.0001). e, f Masson’s trichrome stained Clo-lipo expanded skin at day 14 (n = 5, p < 0.01) and day 35 (n = 8, p < 0.0001) showed a remarkable reduction in collagen density than that of PBS-lipo expanded skin. PBS-lipo, PBS liposomes; Clo-lipo, clodronate liposomes. **p ≤ 0.01; and ****p ≤ 0.0001

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