Fig. 4From: Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse modelTreatment-related activation of peripheral immune cells in female mice bearing tumors. a Peripheral blood mononuclear cells collected 3 days after week 1 treatment were isolated and analyzed by flow cytometry for expression of CD3+, CD3+/CD8+, NKG2D+ and CD3+/NKG2D+ expression. SQ ALT-803 alone resulted in significant increase in CD8, NKG2D and CD3/NKG2D expression cells compared to PBS control. b Splenocytes collected 3 days after week 1 treatment were isolated and analyzed by flow cytometry for expression of CD3+, CD3+/CD8+, NKG2D+ and CD3+/NKG2D+ expression. SQ ALT-803 alone resulted in significant increase in CD3/NKG2D expressing cells compared to PBS controlBack to article page