Fig. 2

Anti-tumor activity of BCG, ALT-803 and ALT-803 plus BCG. a On week 20, mice were sacrificed and resected bladders were fixed in 10% buffered formalin and embedded in paraffin and subsequently stained with H&E. Histopathologic examination of the tumors allowed pathologic stage classification into T0, Ta, T1, Tis and T2. b Bladder weight was reduced in all treatment groups compared to PBS negative control. Greatest reduction in bladder weights was seen in the group treated with ALT-803 SQ, BCG + ALT-803 Ive and BCG + ALT-803 SQ (p < 0.005). c Representative H&E images from each of the six groups are illustrated