Fig. 5

WGCNA analysis of VNP transcriptome. a Module-trait relationship. The top value in each square represent the correlation between the module eigengene and the outcome (disease progression). The brightness of the color means the tightness of correlation. The bottom value is p value of each correlation. Visualization of darkturquiose module (b) and red module (c) which was highly correlated with disease progression with p value less than 0.05 by Cytoscape. Orange nodes denote up-regulated genes in VNPs. The color intensity of each node represents the centrality of gene in the network. The width of each edge represents betweenness