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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

Fig. 2

Patient stratification using the 45-gene signature in HCC cohorts. a Kaplan–Meier plots of overall survival in HCC patients across three cohorts stratified into low- and high-risk groups using the 45-gene signature. P-values were calculated from the log-rank test. b Kaplan–Meier plots show independence of the signature over current staging systems in HCC cohorts. Patients were sub-grouped according to TNM stages and further stratified using the 45-gene signature. The signature successfully identified high-risk patients in different TNM stages. P-values were calculated from the log-rank test. c Analysis of specificity and sensitivity of the signature in HCC cohorts with receiver operating characteristic (ROC). Plots depict comparison of ROC curves of signature and clinical tumor staging parameters. The signature demonstrates an incremental value over current staging systems. AUC: area under the curve. TNM tumor, node, metastasis staging. d Kaplan–Meier plots depicting combined relation of TP53 or CTNNB1 mutation status with the signature on overall survival in HCC

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