Fig. 3

PIAS3 reduces gut inflammation in mice with SpA. a Gut length is shown in the bar graph. b Colon and small intestine tissues were stained with H&E. c Small intestine and colon tissues were stained with specific Abs against IL-17, TNF-α, STAT3, and PIAS3. Pro-inflammatory cytokine-, STAT3-, and PIAS3-positive cells are shown in the bar graph. d Colon and small intestine were stained with specific Abs against CD4 (red) and IL-17 (green). Double-positive cells are shown in the bar graph. Data are represented as the mean ± SEM of three independent experiments (*P < 0.05)