Parameters | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |
Disease-free survival | ||||||
 Age at operation (year) | ||||||
  ≤ 56 | 0.614 | 0.269–1.335 | 0.220 |  |  |  |
  > 56 | ||||||
 Tumour size (mm) | ||||||
  ≤ 27.6 | 1.137 | 0.525–2.503 | 0.744 |  |  |  |
  > 27.6 | ||||||
 Skin infiltration | ||||||
  Negative | 1.556 | 0.455–4.067 | 0.440 |  |  |  |
  Positive | ||||||
 Lymph node status | ||||||
  Negative | 2.440 | 0.933–8.343 | 0.071 | 1.677 | 0.617–5.859 | 0.331 |
  Positive | ||||||
 Ki67 | ||||||
  Negative | 0.394 | 0.180–0.926 | 0.034 | 0.770 | 0.321–1.942 | 0.568 |
  Positive | ||||||
 Intrinsic subtype | ||||||
  HER2-enriched | 1.884 | 0.828–4.823 | 0.135 |  |  |  |
  Triple-negative | ||||||
 ORR | ||||||
  Non-responders | 0.083 | 0.035–0.210 | < 0.001 | 0.154 | 0.059–0.426 | 0.001 |
  Responders | ||||||
 Pathological response | ||||||
  Non-pCR | 0.203 | 0.068–0.499 | < 0.001 | 0.381 | 0.118–1.059 | 0.065 |
  pCR | ||||||
 TILs | ||||||
  Low | 0.252 | 0.107–0.553 | 0.001 | 0.424 | 0.167–1.032 | 0.059 |
  High | ||||||
 Pack-years | ||||||
  Low | 0.434 | 0.127–1.134 | 0.092 | 0.567 | 0.160–1.555 | 0.289 |
  High | ||||||
Overall survival | ||||||
 Age at operation (year) | ||||||
  ≤ 56 | 0.508 | 0.175–1.338 | 0.172 |  |  |  |
  > 56 | ||||||
 Tumour size (mm) | ||||||
  ≤ 27.6 | 1.123 | 0.429–2.993 | 0.811 |  |  |  |
  > 27.6 | ||||||
 Skin infiltration | ||||||
  Negative | 1.939 | 0.446–5.977 | 0.335 |  |  |  |
  Positive | ||||||
 Lymph node status | ||||||
  Negative | 2.778 | 0.781–17.657 | 0.125 |  |  |  |
  Positive |  |  |  |  |  |  |
 Ki67 | ||||||
  Negative | 0.638 | 0.234–2.023 | 0.419 |  |  |  |
  Positive | ||||||
 Intrinsic subtype | ||||||
  HER2-enriched | 1.610 | 0.597–5.060 | 0.357 |  |  |  |
  Triple-negative | ||||||
 ORR | ||||||
  Non-responders | 0.077 | 0.026–0.238 | < 0.001 | 0.451 | 0.044–0.520 | 0.004 |
  Responders | ||||||
 Pathological response | ||||||
  Non-pCR | 0.183 | 0.042–0.561 | 0.002 | 0.282 | 0.062–0.953 | 0.041 |
  pCR | ||||||
 TILs | ||||||
  Low | 0.357 | 0.129–0.929 | 0.035 | 0.634 | 0.212–1.861 | 0.403 |
  High | ||||||
 Pack-years | ||||||
  Low | 0.554 | 0.128–1.700 | 0.325 |  |  |  |
  High |