Skip to main content

Advertisement

Fig. 1 | Journal of Translational Medicine

Fig. 1

From: The emerging role of WISP proteins in tumorigenesis and cancer therapy

Fig. 1

A schematic diagram of the structure of WISP proteins. WISP proteins have four highly conserved cysteine-rich motifs, which include the N-terminal motif, the von Willebrand factor-like (VWC) motif, the thrombospondin type 1 (TSP-1) motif, and the carboxy-terminal (CT) motif. The N-terminal motif consists of the first 12 cysteine residues and the IGF binding consensus sequence (GCGCCXXC). VWC and TSP1 motifs are involved in cell–cell interactions and angiogenesis inhibition. The CT motif forms a cysteine knot. WISP2 lacks the CT module

Back to article page