Fig. 3
From: MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo
a Inverse correlations of microRNAs and messenger RNAs with relevance to angiogenesis. Deregulated microRNAs (miRNAs) and messenger RNAs (mRNAs) with significant inverse correlations as well as association with angiogenesis-related gene ontology (GO) terms and predicted target interactions according to TargetScan. Green background: up-regulated mRNAs. Red background: down-regulated mRNAs. Connections between miRNAs and mRNAs represent significant inverse correlations (r < − 0.5, P < 5 × 10−5). b Schematic workflow of the study for identification of miRNA-regulated pathways in flow-stimulated angiogenesis. Spearman correlation plots show significant inverse correlations between the expression levels of synaptojanin-2 binding protein (SYNJ2BP) and miR-449-5p (c) as well as miR 223-3p (d), ephrin receptor kinase 2 (EPHA2) and miR-223-3p (e), forkhead box C1 (FOXC1) and miR-511-3p (f), interleukin-1 alpha (IL1A) and miR-27b-3p (g), as well as C–X–C chemokine receptor 2 and let-7b-5p (h)