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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma

Fig. 2

Overexpression of miR-34c inhibits migration, invasion and proliferation and limits EMT in NPC cells. CNE-2, 5–8F and CNE-2R cells were transfected with miR-34c control (miR-Ctrl), mimics (miR-34c-m) or inhibitors (miR-34c-i). a Cell migration was assessed using Transwell migration and invasion assays (10 times magnification). b, c The number of cells per field in a migration and invasion assay. d Western blot analysis of EMT-related markers in CNE-2 and 5–8F cells transfected with lentivirus from each group. Gray value shows in the right panel. e Photos of colonies of NPC cells in colony formation assays. f The number of colonies in different groups. g Cell proliferation in each group of CNE-2, 5–8F and CNE-2R cells was measured by CCK8 assay (the results were reproduced in three independent experiments.*P < 0.05; **P < 0.01; ***P < 0.001; ns: no statistical significance)

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