Fig. 1

Expression of miR-34c is downregulated in NPC cells and tissues and associated with radioresistance in patients with NPC. a, b Heatmap displaying miRNA expression in NP69, CNE-2, and CNE-2R cells; miR-34c was selected for further study. c Waterfall plot showing the relative expression of miR-34c in NPC tissues (NCBI/GEO/GSE70970). d Pie chart displaying the miR-34c levels in NPC tissues; a fold change > 2 or < 1/2 in relative miR-34c expression was defined as significant. e The miR-34c levels in tissues from radioresistant patients (n = 29) and radiosensitive patients (n = 41) were measured by qRT-PCR. f The miR-34c levels in NP-460, NP69, CNE-2, 6–10B, 5–8F and CNE-2R cells were measured by qRT-PCR. g Kaplan–Meier curve for overall survival in the cohort of 185 NPC patients (NCBI/GEO/GSE70970). Patients were divided into two groups based on miR-34c level in each sample, and the median ratio value was chosen as the cutoff point