Fig. 5

Functional characterizations of the 106-CDS panel. a Volcano plot of differently expressed genes (DE genes) between the high-TMB and low-TMB groups predicted via the 106-CDS panel. The list of DE genes is shown in Additional file 5: Table S4. The pink and blue circles represent the up-regulated and down-regulated DE genes in the predicted high-TMB group when compared with the predicted low-TMB group. The gray circle represent the genes without different expression between the predicted high-TMB and low-TMB groups. b The top 10 functional pathways significantly enriched with DE genes between the high-TMB and low-TMB groups predicted via the 106-CDS panel. All 22 functional pathways are shown in Additional file 6: Table S5. The size of nodes represents the number of DE genes in the pathway. The colour of the nodes, from green to red, represents the p-value of enrichment results from high to low. The ratios represent the proportion of DE genes enriched in the pathway to the total number of genes in the pathway