Table 4 RCTs with pharmacological and non-pharmacological combined interventions
Intervention | Design, N. of participants | Period (week), dose | Primary measurement | Significance |
|---|---|---|---|---|
Fluoxetine + graded exercise [70] | Exercise + fluoxetine: 33 Exercise + placebo: 34 Appointment + fluoxetine: 35 Appointment + placebo: 34 | 24 20 mg/day | Chalder scale | Graded exercise P < 0.05 |
Dialyzable leukocyte extract (DLE) + CBT [71] | DLE + CBT: 20 DLE + clinic: 26 Placebo + CBT: 21 Placebo + clinic: 23 | 28 5·108 leukocytes 8 times biweekly | VAS (global well-being) | Not significant |