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Table 4 RCTs with pharmacological and non-pharmacological combined interventions

From: Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

Intervention Design, N. of participants Period (week), dose Primary measurement Significance
Fluoxetine + graded exercise [70] Exercise + fluoxetine: 33
Exercise + placebo: 34
Appointment + fluoxetine: 35
Appointment + placebo: 34
24
20 mg/day
Chalder scale Graded exercise
P < 0.05
Dialyzable leukocyte extract (DLE) + CBT [71] DLE + CBT: 20
DLE + clinic: 26
Placebo + CBT: 21
Placebo + clinic: 23
28
5·108 leukocytes
8 times biweekly
VAS (global well-being) Not significant
  1. VAS Visual Analogue Scale