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Table 2 Overview of immune system (OVIS)

From: Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α

Cell populationsControls (n = 20)CML patientsp value#
Mean95% CITKIs (n = 33)TKIs plus IFN-α (n = 8)
Mean95% CIp valueMean95% CIp value
Granulocytes3971.9(3195.1–4937.6)3752.5(3167.6–4445.3)1.0004051.7(2872.1–5715.9)1.0001.000
Monocytes328.7(261.2–413.6)381.5(319.0–456.2)0.930466.4(324.4–670.7)0.3260.973
CD45low140.9(104.5–189.9)64.8(51.4–81.8)0.00156.1(35.0–90.0)0.0051.000
Lymphocytes2059.4(1660.5–2554.1)1852.7(1566.9–2190.8)1.0001140.3(811.3–1602.6)0.0140.039
 B cells241.9(176.2–332.1)147.9(115.6–189.3)0.052171.6(104.0–283.1)0.7511.000
 T cells1500.3(1207.0–1864.9)1324.3(1118.0–1568.7)1.000837.9(594.1–1181.9)0.0170.060
  CD4+1016.4(813.2–1270.4)758.0(637.1–901.7)0.104504.7(354.7–718.1)0.0040.105
    Naive358.5(264.0–486.9)230.7(181.8–292.7)0.067173.1(103.2–290.3)0.0480.573
    Central memory (CM)344.3(271.2–437.1)238.3(197.9–286.9)0.047183.8(122.8–275.1)0.0260.475
    Effector memory (EM)13.7(6.9–27.1)18.2(10.7–31.0)0.7917.1(2.2–22.6)0.5960.311
    EM CD45 RA+ (EMRA)4.2(2.1–8.1)11.9(7.0–20.1)0.0444.6(1.5–14.3)0.9880.289
  CD8+207.1(152.5–281.4)327.7(258.2–416.0)0.055193.2(119.0–313.7)0.9680.132
    Naive42.9(29.1–63.2)51.7(38.2–69.8)0.73057.2(31.0–105.5)0.7080.952
    Central memory (CM)39.5(28.7–54.3)48.1(37.5–61.6)0.59535.6(21.5–58.9)0.9360.536
    Effector memory (EM)5.2(2.9–9.4)19.7(12.4–31.2)0.00210.5(4.1–26.8)0.4110.454
    EM CD45 RA+ (EMRA)13.3(7.5–23.6)74.7(47.7–117.0)0.00123.0(9.3–57.2)0.5660.060
  CD4+/CD8+228.3(168.0–310.2)126.3(99.5–160.3)0.00982.0(50.5–133.1)0.0020.253
 NK cells243.4(175.1–338.3)233.4(180.7–301.6)1.000159.1(94.6–267.7)0.5170.573
  CD56Dim243.3(174.0–340.2)266.2(205.1–345.6)0.906135.8(80.0–230.7)0.1590.067
  CD56Bright11.2(7.3–17.3)6.3(4.5–8.8)0.09228.6(14.5 - 56.5)0.0600.001
 CD56+ T cells60.6(36.9–99.6)41.4(28.1–61.0)0.6978.8(4.019.4)0.0010.002
  CD4+14.0(8.7–22.5)7.9(5.4–11.5)0.1542.4(1.05.7)0.0020.039
  CD8+15.8(9.3–26.8)19.0(12.4–29.1)0.8486.6(2.5–17.3)0.2590.119
  CD4+/CD8+22.0(13.4–36.3)9.8(6.614.7)0.0383.6(1.48.9)0.0030.111
  1. p value: statistical comparison vs control. p value # statistical comparison between TKIs and TKIs plus IFN-α. Cell populations with p < 0.050 are highlighted in italic