Table 2 Overview of immune system (OVIS)
Cell populations | Controls (n = 20) | CML patients | p value# | ||||||
|---|---|---|---|---|---|---|---|---|---|
Mean | 95% CI | TKIs (n = 33) | TKIs plus IFN-α (n = 8) | ||||||
Mean | 95% CI | p value | Mean | 95% CI | p value | ||||
Granulocytes | 3971.9 | (3195.1–4937.6) | 3752.5 | (3167.6–4445.3) | 1.000 | 4051.7 | (2872.1–5715.9) | 1.000 | 1.000 |
Monocytes | 328.7 | (261.2–413.6) | 381.5 | (319.0–456.2) | 0.930 | 466.4 | (324.4–670.7) | 0.326 | 0.973 |
CD45low | 140.9 | (104.5–189.9) | 64.8 | (51.4–81.8) | 0.001 | 56.1 | (35.0–90.0) | 0.005 | 1.000 |
Lymphocytes | 2059.4 | (1660.5–2554.1) | 1852.7 | (1566.9–2190.8) | 1.000 | 1140.3 | (811.3–1602.6) | 0.014 | 0.039 |
B cells | 241.9 | (176.2–332.1) | 147.9 | (115.6–189.3) | 0.052 | 171.6 | (104.0–283.1) | 0.751 | 1.000 |
T cells | 1500.3 | (1207.0–1864.9) | 1324.3 | (1118.0–1568.7) | 1.000 | 837.9 | (594.1–1181.9) | 0.017 | 0.060 |
CD4+ | 1016.4 | (813.2–1270.4) | 758.0 | (637.1–901.7) | 0.104 | 504.7 | (354.7–718.1) | 0.004 | 0.105 |
Naive | 358.5 | (264.0–486.9) | 230.7 | (181.8–292.7) | 0.067 | 173.1 | (103.2–290.3) | 0.048 | 0.573 |
Central memory (CM) | 344.3 | (271.2–437.1) | 238.3 | (197.9–286.9) | 0.047 | 183.8 | (122.8–275.1) | 0.026 | 0.475 |
Effector memory (EM) | 13.7 | (6.9–27.1) | 18.2 | (10.7–31.0) | 0.791 | 7.1 | (2.2–22.6) | 0.596 | 0.311 |
EM CD45 RA+ (EMRA) | 4.2 | (2.1–8.1) | 11.9 | (7.0–20.1) | 0.044 | 4.6 | (1.5–14.3) | 0.988 | 0.289 |
CD8+ | 207.1 | (152.5–281.4) | 327.7 | (258.2–416.0) | 0.055 | 193.2 | (119.0–313.7) | 0.968 | 0.132 |
Naive | 42.9 | (29.1–63.2) | 51.7 | (38.2–69.8) | 0.730 | 57.2 | (31.0–105.5) | 0.708 | 0.952 |
Central memory (CM) | 39.5 | (28.7–54.3) | 48.1 | (37.5–61.6) | 0.595 | 35.6 | (21.5–58.9) | 0.936 | 0.536 |
Effector memory (EM) | 5.2 | (2.9–9.4) | 19.7 | (12.4–31.2) | 0.002 | 10.5 | (4.1–26.8) | 0.411 | 0.454 |
EM CD45 RA+ (EMRA) | 13.3 | (7.5–23.6) | 74.7 | (47.7–117.0) | 0.001 | 23.0 | (9.3–57.2) | 0.566 | 0.060 |
CD4+/CD8+ | 228.3 | (168.0–310.2) | 126.3 | (99.5–160.3) | 0.009 | 82.0 | (50.5–133.1) | 0.002 | 0.253 |
NK cells | 243.4 | (175.1–338.3) | 233.4 | (180.7–301.6) | 1.000 | 159.1 | (94.6–267.7) | 0.517 | 0.573 |
CD56Dim | 243.3 | (174.0–340.2) | 266.2 | (205.1–345.6) | 0.906 | 135.8 | (80.0–230.7) | 0.159 | 0.067 |
CD56Bright | 11.2 | (7.3–17.3) | 6.3 | (4.5–8.8) | 0.092 | 28.6 | (14.5 - 56.5) | 0.060 | 0.001 |
CD56+ T cells | 60.6 | (36.9–99.6) | 41.4 | (28.1–61.0) | 0.697 | 8.8 | (4.0–19.4) | 0.001 | 0.002 |
CD4+ | 14.0 | (8.7–22.5) | 7.9 | (5.4–11.5) | 0.154 | 2.4 | (1.0–5.7) | 0.002 | 0.039 |
CD8+ | 15.8 | (9.3–26.8) | 19.0 | (12.4–29.1) | 0.848 | 6.6 | (2.5–17.3) | 0.259 | 0.119 |
CD4+/CD8+ | 22.0 | (13.4–36.3) | 9.8 | (6.6–14.7) | 0.038 | 3.6 | (1.4–8.9) | 0.003 | 0.111 |