Fig. 6

Gene expression profiling of blood samples from patients with CML receiving TKIs, either alone or in combination with IFN-α. a Unsupervised hierarchical clustering of immune cell type-specific scores in patients treated with IFN-α and TKIs or with TKIs alone. Data were analyzed and visualized using an on-line resource (Morpheus; Broad Institute, MA, USA). b Correlation matrix (Pearson correlation coefficients) of immune cell type-specific scores in patients treated with TKIs plus IFN-α or with TKIs alone. Dark red denotes high correlation, dark blue denotes anti-correlation and white denotes a lack of correlation. c Unsupervised hierarchical clustering of signature scores in patients treated with IFN-α and TKIs or with TKIs alone. d Correlation matrix (Pearson correlation coefficients) of signature scores in patients treated with TKIs plus IFN-α or with TKIs alone. Dark red denotes high correlation, dark blue denotes anti-correlation and white denotes a lack of correlation. e Volcano plot showing differentially expressed (DE) genes in patients receiving IFN-α and TKIs compared with patients treated with TKIs alone. The top DE genes (linear fold-change > 4 or < 2 with a p value < 0.01) are highlighted in red (up-regulated) and green (down-regulated). The dotted horizontal lines indicate p values < 0.05 and < 0.01