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Table 4 Based on the marker expression in transforming OLP (group 1) and non-transforming OLP (group 2), eligibility of macrophage infiltration (CD68 epithelial, CD68 subepithelial, CD163 epithelial) as predictive test for malignant transformation was analyzed

From: Malignant transformation of oral leukoplakia is associated with macrophage polarization

 

AUC

COP

No. of cases

+

−

% pos. cases (%)

p-value χ2 test

Sensitivity

Specificity

Positive predictive value

Negative predictive value

CD68 epithelial

0.660

2.92

103

70

33

 

0.003

58.6%

72.7%

0.820

0.453

 Transforming OLP

  

50

41

9

82.0

     

 Non-transforming OLP

  

53

29

24

54.7

     

CD68 subepithelial

0.773

95.18

99

50

49

 

< 0.001

72.0%

73.5%

0.735

0.720

 Transforming OLP

  

49

36

13

73.5

     

 Non-transforming OLP

  

50

14

36

28.0

     

CD163 epithelial

0.724

1.12

96

63

33

 

0.010

55.6%

72.7%

0.795

0.462

 Transforming OLP

  

44

35

9

79.5

     

 Non-transforming OLP

  

52

28

24

53.8

     
  1. Area under the curve (AUC) and cut-off point (COP) values are given. Based on their marker expression value (positive cells/mm2) related to the COP, the cases were determined as positive (malignant transformation expected) and negative (no malignant transformation expected). The percentage of positive tested cases (% pos. cases) in transforming OLP (group 1) and non-transforming OLP (group 2) is presented. A statistical analysis was carried out by the Chi-square test (χ2 test). Sensitivity, specificity, positive- and negative predictive value of macrophage infiltration (positive cells/mm2) for the prediction of malignant transformation are given
  2. AUC, area under the curve; COP, cut-off point; OLP, oral leukoplakia; +, positive cases in χ2 test; −, positive cases in χ2 test